USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P35241 USC-OGP 2-DE database:  P35241 P35241 General information about the entry View entry in simple text format Entry name RADI_HUMAN Primary accession number P35241 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Radixin;. Gene name Name=RDX Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1120: pI=6.09; Mw=84978 Cross-references UniProtKB/Swiss-Prot P35241; RADI_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name RADI_HUMAN Primary accession number P35241 Secondary accession number(s) A7YIJ8 A7YIK0 A7YIK3 B7Z9U6 F5H1A7 Q86Y61 Sequence was last modified on  February 1, 1994 (version 1) Annotations were last modified on  March 15, 2017 (version 163) Name and origin of the protein Description RecName: Full=Radixin; Gene name Name=RDX Encoded on Name=RDX Keywords Actin capping; Actin-binding; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Disease mutation; Membrane; Non-syndromic deafness; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L02320; AAA36541.1; -; mRNA EMBL AK316061; BAH14432.1; -; mRNA EMBL DQ916738; ABI34710.1; -; mRNA EMBL DQ916739; ABI34711.1; -; mRNA EMBL DQ916741; ABI34713.1; -; mRNA EMBL DQ916742; ABI34714.1; -; mRNA EMBL DQ916740; ABI34712.1; -; mRNA EMBL AP000901; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP002788; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471065; EAW67129.1; -; Genomic_DNA EMBL BC047109; AAH47109.1; -; mRNA CCDS CCDS58171.1; -. [P35241-2]; . CCDS CCDS58172.1; -. [P35241-4]; . CCDS CCDS58173.1; -. [P35241-3]; . CCDS CCDS58174.1; -. [P35241-5]; . CCDS CCDS8343.1; -. [P35241-1]; . PIR A46127; A46127; . RefSeq NP_001247421.1; NM_001260492.1. [P35241-5]; . RefSeq NP_001247422.1; NM_001260493.1. [P35241-5]; . RefSeq NP_001247423.1; NM_001260494.1. [P35241-4]; . RefSeq NP_001247424.1; NM_001260495.1. [P35241-2]; . RefSeq NP_001247425.1; NM_001260496.1. [P35241-3]; . RefSeq NP_002897.1; NM_002906.3. [P35241-1]; . UniGene Hs.263671; -; . UniGene Hs.584560; -; . UniGene Hs.741211; -; . ProteinModelPortal P35241; -; . SMR P35241; -; . BioGrid 111894; 71; . IntAct P35241; 11; . MINT MINT-1536950; -; . STRING 9606.ENSP00000342830; -; . iPTMnet P35241; -; . PhosphoSitePlus P35241; -; . SwissPalm P35241; -; . BioMuta RDX; -; . DMDM 464541; -; . EPD P35241; -; . MaxQB P35241; -; . PaxDb P35241; -; . PeptideAtlas P35241; -; . PRIDE P35241; -; . Ensembl ENST00000343115; ENSP00000342830; ENSG00000137710. [P35241-1]; . Ensembl ENST00000405097; ENSP00000384136; ENSG00000137710. [P35241-5]; . Ensembl ENST00000528498; ENSP00000432112; ENSG00000137710. [P35241-5]; . Ensembl ENST00000528900; ENSP00000433580; ENSG00000137710. [P35241-2]; . Ensembl ENST00000530301; ENSP00000436277; ENSG00000137710. [P35241-3]; . Ensembl ENST00000530749; ENSP00000437301; ENSG00000137710. [P35241-5]; . Ensembl ENST00000544551; ENSP00000445826; ENSG00000137710. [P35241-4]; . GeneID 5962; -; . KEGG hsa:5962; -; . UCSC uc001pku.4; human. [P35241-1]; . CTD 5962; -; . DisGeNET 5962; -; . GeneCards RDX; -; . GeneReviews RDX; -; . HGNC HGNC:9944; RDX; . HPA CAB037312; -; . HPA HPA000263; -; . HPA HPA000763; -; . MalaCards RDX; -; . MIM 179410; gene; . MIM 611022; phenotype; . neXtProt NX_P35241; -; . OpenTargets ENSG00000137710; -; . Orphanet 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB; . PharmGKB PA34311; -; . eggNOG KOG3529; Eukaryota; . eggNOG ENOG410XQFP; LUCA; . GeneTree ENSGT00860000133686; -; . HOGENOM HOG000007113; -; . HOVERGEN HBG002185; -; . InParanoid P35241; -; . KO K05762; -; . OMA LSREDSM; -; . OrthoDB EOG091G06UO; -; . PhylomeDB P35241; -; . TreeFam TF313935; -; . Reactome R-HSA-437239; Recycling pathway of L1; . SIGNOR P35241; -; . ChiTaRS RDX; human; . GeneWiki Radixin; -; . GenomeRNAi 5962; -; . PRO PR:P35241; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000137710; -; . CleanEx HS_RDX; -; . ExpressionAtlas P35241; baseline and differential; . Genevisible P35241; HS; . GO GO:0016324; C:apical plasma membrane; IDA:UniProtKB; . GO GO:0071944; C:cell periphery; IDA:UniProtKB; . GO GO:0051286; C:cell tip; IEA:Ensembl; . GO GO:0005913; C:cell-cell adherens junction; IEA:Ensembl; . GO GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell; . GO GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0019898; C:extrinsic component of membrane; IEA:InterPro; . GO GO:0030175; C:filopodium; ISS:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030027; C:lamellipodium; ISS:UniProtKB; . GO GO:0005902; C:microvillus; ISS:UniProtKB; . GO GO:0030496; C:midbody; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0001726; C:ruffle; IEA:Ensembl; . GO GO:0032420; C:stereocilium; IEA:Ensembl; . GO GO:0030315; C:T-tubule; IEA:Ensembl; . GO GO:0003779; F:actin binding; IDA:UniProtKB; . GO GO:0051117; F:ATPase binding; IPI:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0042803; F:protein homodimerization activity; ISS:UniProtKB; . GO GO:0051018; F:protein kinase A binding; ISS:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0045176; P:apical protein localization; IEA:Ensembl; . GO GO:0051016; P:barbed-end actin filament capping; IEA:Ensembl; . GO GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl; . GO GO:0097067; P:cellular response to thyroid hormone stimulus; ISS:UniProtKB; . GO GO:0061028; P:establishment of endothelial barrier; IGI:UniProtKB; . GO GO:0045184; P:establishment of protein localization; ISS:UniProtKB; . GO GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProtKB; . GO GO:0030033; P:microvillus assembly; IEA:Ensembl; . GO GO:1903392; P:negative regulation of adherens junction organization; IMP:UniProtKB; . GO GO:0045792; P:negative regulation of cell size; IMP:UniProtKB; . GO GO:0034260; P:negative regulation of GTPase activity; IMP:UniProtKB; . GO GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IMP:UniProtKB; . GO GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB; . GO GO:1903364; P:positive regulation of cellular protein catabolic process; IGI:UniProtKB; . GO GO:2000643; P:positive regulation of early endosome to late endosome transport; IGI:UniProtKB; . GO GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IGI:UniProtKB; . GO GO:1902966; P:positive regulation of protein localization to early endosome; IGI:UniProtKB; . GO GO:0010737; P:protein kinase A signaling; ISS:UniProtKB; . GO GO:0032231; P:regulation of actin filament bundle assembly; IMP:UniProtKB; . GO GO:0008360; P:regulation of cell shape; IMP:UniProtKB; . GO GO:0008361; P:regulation of cell size; IGI:UniProtKB; . GO GO:0043087; P:regulation of GTPase activity; IGI:UniProtKB; . GO GO:1902115; P:regulation of organelle assembly; IGI:UniProtKB; . GO GO:0032487; P:regulation of Rap protein signal transduction; ISS:UniProtKB; . GO GO:1900027; P:regulation of ruffle assembly; IMP:UniProtKB; . Gene3D 1.20.80.10; -; 1; . Gene3D 2.30.29.30; -; 1; . InterPro IPR019749; Band_41_domain; . InterPro IPR011174; ERM; . InterPro IPR011259; ERM_C_dom; . InterPro IPR000798; Ez/rad/moesin-like; . InterPro IPR014352; FERM/acyl-CoA-bd_prot_3-hlx; . InterPro IPR019748; FERM_central; . InterPro IPR019747; FERM_CS; . InterPro IPR000299; FERM_domain; . InterPro IPR018979; FERM_N; . InterPro IPR018980; FERM_PH-like_C; . InterPro IPR008954; Moesin_tail; . InterPro IPR011993; PH_dom-like; . InterPro IPR029071; Ubiquitin-rel_dom; . Pfam PF00769; ERM; 1; . Pfam PF09380; FERM_C; 1; . Pfam PF00373; FERM_M; 1; . Pfam PF09379; FERM_N; 1; . PIRSF PIRSF002305; ERM; 1; . PRINTS PR00935; BAND41; . PRINTS PR00661; ERMFAMILY; . SMART SM00295; B41; 1; . SMART SM01196; FERM_C; 1; . SUPFAM SSF47031; SSF47031; 1; . SUPFAM SSF48678; SSF48678; 1; . SUPFAM SSF50729; SSF50729; 1; . SUPFAM SSF54236; SSF54236; 1; . PROSITE PS00660; FERM_1; 1; . PROSITE PS00661; FERM_2; 1; . PROSITE PS50057; FERM_3; 1; .

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